Metformin links #Kani

Links in search of trying to identify low melting point compound: http://www.manusaktteva.com/api/Metformin http://www.yoseme.com/product...

'Toluene method' #Kani

All seemed very promising with the 'toluene method' today, with a molten clear product forming white crystals upon recrystallization from...

Isoxazolines for veterinary use #Ngozi

Thought I'd do a quick google search on isoxazolines and found this interesting web page: http://parasitipedia.net/index.php?option=com_c...

Metformin synthesis patents #Kani

Found this patent http://www.google.co.uk/patents/WO2010146604A2?cl=en Looks very worth pursuing. Essentially a reflux in toluene...

Simple but relevant 1,3-dipolar cycloadditions #Ngozi

Ngozi mentioned difficulty in finding pharmacy relevant, but simple 1,3-dipolar cycloaddition reactions that could be carried out as...

Solvent for MDI #Roshni

Roshni suggests N,N-dimethylacetamide (DMAc) might be good to dissolve the MDI rather than chloroform, from paper: Xiang-Dong Sun and...

Isoxazoline and Isoxazole rings #Ngozi

Realised at the weekend that 3,5-diphenylisoxazole, which we looked at the SDS for (Sigma) and which we thought was...

1,3-Dipolar cycloaddition reactions: Next steps #Ngozi

The main aim of the project is to produce educational materials that highlight the relevance of this important reaction in synthetic...

Metformin reaction mechanism #Kani

Recalled a chat with Eugen about metformin synthesis may have an equilibrium between the dimethylamine hydrochloride and the free...

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